Josh Conway

In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of fat With the decrease in metabolic activity that frequently occurs with aging, human beings often accumulate fat. This fat, itself, also ages; this paper describes it...

Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A common cause of lower back problems Intervertebral disc degeneration (IDD) is one of the core reasons for lower back pain in older people. This nearly ubiquitous problem is a frequent target...

Researchers publishing in Cell Reports Medicine have described the development of a lipid nanoparticle (LNP) that delivers mRNA to neurons in order to stop the formation of tau aggregates and fight Alzheimer's disease. Tau and amyloids Amyloid beta deposition between neurons and tau aggregation within neurons are both hallmarks of Alzheimer's disease, and evidence suggests...

Researchers publishing in Aging Cell have discovered that the nuclei of the cells that line injured arteries quickly become misshapen and that this leads to accelerated cellular senescence. Delivering zinc to these cells partially alleviates this dysmorphism. Two seemingly unrelated concepts This paper begins with a discussion of two different concepts that, on the surface,...

A group of researchers, including Matthew O'Connor of Cyclarity Therapeutics, has published a review detailing what effects 7-ketocholesterol (7KC) has in the human body. An oxidized cholesterol 7KC, an oxidized cholesterol (oxysterol) gets its name from being oxidized at the C7 position within the cholesterol molecule [1]. This compound is formed by non-enzymatic processes driven...

The European Heart Journal has published a review of what happens to the human heart as it ages, noting the cellular effects of mitochondrial dysfunction and cellular senescence along with more visible changes such as hypertrophy and fibrosis. A constantly working organ The reviewers begin this paper by noting the constant work of the heart,...